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cancer-testis 1

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fluorescent probe 1

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lipoylation modification 1

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Histone variants: critical determinants in tumour heterogeneity

Tao Wang, Florent Chuffart, Ekaterina Bourova-Flin, Jin Wang, Jianqing Mi, Sophie Rousseaux, Saadi Khochbin

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 289-297 doi: 10.1007/s11684-018-0667-3

Abstract: Malignant cell transformation could be considered as a series of cell reprogramming events driven by oncogenic transcription factors and upstream signalling pathways. Chromatin plasticity and dynamics are critical determinants in the control of cell reprograming. An increase in chromatin dynamics could therefore constitute an essential step in driving oncogenesis and in generating tumour cell heterogeneity, which is indispensable for the selection of aggressive properties, including the ability of cells to disseminate and acquire resistance to treatments. Histone supply and dosage, as well as histone variants, are the best-known regulators of chromatin dynamics. By facilitating cell reprogramming, histone under-dosage and histone variants should also be crucial in cell transformation and tumour metastasis. Here we summarize and discuss our knowledge of the role of histone supply and histone variants in chromatin dynamics and their ability to enhance oncogenic cell reprogramming and tumour heterogeneity.

Keywords： cancer-testis     TH2B     TH2A     H1T     H1.0     H1F0     linker histones    

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A dual-function chemical probe for detecting erasers of lysine lipoylation

Yusheng Xie, Jie Zhang, Liu Yang, Qingxin Chen, Quan Hao, Liang Zhang, Hongyan Sun

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1,   Pages 121-127 doi: 10.1007/s11705-021-2051-0

Abstract: Affinity-based labeling probe using photo-cross-linker is a powerful platform to study the transient

Keywords： dual-function     fluorescent probe     labeling     photo-cross-linker     lipoylation modification     eraser     sirtuin    

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Title Author Date Type Operation

Histone variants: critical determinants in tumour heterogeneity

Tao Wang, Florent Chuffart, Ekaterina Bourova-Flin, Jin Wang, Jianqing Mi, Sophie Rousseaux, Saadi Khochbin

Journal Article

A dual-function chemical probe for detecting erasers of lysine lipoylation

Yusheng Xie, Jie Zhang, Liu Yang, Qingxin Chen, Quan Hao, Liang Zhang, Hongyan Sun

Journal Article